Keerthi Thirtamara

B.S. in Pharmacy, Sri Ramachandra Medical College and Research Institute
M.S. in Pharmacology, The Ohio State University

Thesis Advisor:  Howard Gu

E-Mail: thirtamara-rajam.1@osu.edu    

Research:

Autism is a neurodevelopmental disorder characterized by abnormalities in reciprocal social interaction, communication, repetitive interests and behaviors. Twin studies show a 25% discordance rate, suggesting that environmental factors play an important role in autism. Recent clinical studies suggest that events in utero environment are associated with Autism. We hypothesize that certain chemicals dietary compound, such as food preservatives are environmental risk factors to a subset of Autistic incidences. Though these compounds are strictly regulated by the USFDA most of them have been certified as GRAS (generally regarded as safe) a conclusion USFDA comes to based on scientific evidence concerning their use or by their history of use prior to 1958. Now most compounds used as Additives are tested for potential toxicity to various organs of the human body, almost none are for any toxicity resulting in behavioral deficits. We are specifically interested in looking at any behavioral deficits resulting from the consumption of these food additives. Recent advances have identified certain behavioral tasks that identify Autistic-like behavior in mice with reasonable face and construct validity to symptoms seen in humans, like reduced social interaction and repetitive behavior. We are currently exposing pregnant mice to commonly used Food additives/preservatives/colors and testing whether their pups show autistic-like behaviors. These studies may identify dietary compounds that contribute to autism.